Research Studies

The COVID-19 Genomics UK (COG-UK) Consortium will be conducting a number of studies to understand more about the transmission and evolution of the SARS-CoV-2 virus over time.

COG-UK Hospital Onset Covid-19 Infection (HOCI) Study

COG-UK Hospital Onset Covid-19 Infection (HOCI) StudyCOG-UK HOCI is a phase III prospective, interventional, cohort, superiority study to evaluate the benefit of rapid COVID-19 genomic sequencing on infection control in preventing the spread of the virus in United Kingdom NHS hospitals.

Aims

The study has two aims:

  1. To measure whether rapid (<48 hours) COVID-19 sequencing better defines Hospital Onset COVID-19 Infection (HOCI) and
  2. To measure whether rapid COVID-19 sequencing can be used to reduce COVID 19 outbreaks
Participating organisations

The study will initially involve five of the COG-UK participants:

  • UCL
  • Imperial Healthcare Trust
  • Glasgow
  • Sheffield
  • Guys and St Thomas Trust.
Documentation

Genetics Of Mortality In Critical Care - The GenOMICC Study

GenOMICC logo

GenOMICC is an open, collaborative, global community of doctors and scientists trying to understand and treat critical illness. Partners in the study have been recruiting patients since 2016 to study emerging infections (SARS/MERS/Flu), sepsis, and other forms of critical illness. It is the largest study of its kind anywhere in the world.

GenOMICC, in partnership Genomics England, Illumina and the NHS, now aims to sequence the genomes of thousands of patients severely ill with coronavirus. The genomes will be analysed with the aim of understanding how a person’s genetics may influence their susceptibility to the virus.

This data, from the person’s own genome, will be linked to the virus genome data provided via COG-UK. This may provide unique insights into how the patient and virus genomes act together to influence the patient’s response to the infection, and will help inform and improve responses to future outbreaks.

Selective survey of COVID-19 related research published worldwide

To aid COG-UK Consortium research partners, the Consortium posts a selected list of genomic research studies published around the world on COVID-19. The files are available in PDF format, click on the links to download: