Blog

8 May 2020

Commentary: COG-UK Report 5, 7th May 2020

Commentary

Commentary: COG-UK Report 5, 7th May 2020

The 5th report from COG-UK includes analysis of a total of 10,483 SARS-CoV-2 genomes, sequenced before 7th May 2020.

The report also includes analysis of viral genomes sequenced from five care homes in London. The samples were taken from staff and residents between 13th and 15th of April 2020. Of the 210 samples assessed, 91 were positive for SARS-CoV-2. 55 of these samples were of high enough quality for analysis. These data were used for phylogenetic studies within each care home, and for comparison with 277 non-care home viral genomes originating in London.

Analysis of the data suggests that in one care home, there were at least four separate introductions of the virus. A similar pattern of multiple introductions of the virus was observed in two other care homes, although less data were available for these sites. There was also some evidence that following an introduction of the virus, in some cases, there was transmission within a care home.

No common pattern or direction was seen for transmission, either between staff and residents or between symptomatic and asymptomatic people.

Further analysis identified a putative cluster of viral sequences, containing samples from multiple care homes. The presence of similar sequences across different care homes could suggest either transmission of SARS-CoV-2 between care homes, or separate introductions of the same viral lineage to different care homes from the community or other healthcare settings. Since the completion of this report, additional sequence data have been analysed. This analysis indicated that the sequences from care homes are part of a widespread viral lineage and consequently it is not possible to determine which of these scenarios is the case.

The findings highlight the importance of ongoing, larger studies, with additional metadata. Such studies will be vital to study transmission in care settings and inform control strategies.

The researchers anticipate that as the number of genomes sequenced increases, they will be able to provide a high resolution view of viral lineage diversity in the UK. This will make it possible to distinguish dominant local lineages and track viral spread from one part of the UK to another.

In such a fast-moving situation, the consortium members note it is important to consider the limitations of phylogenetic analysis, and the importance of caveats when interpreting data.

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Women in COG: in conversation with Professor Emma Thomson

On Wednesday 29th June, at 12:15 – 13:00 BST, we will be hosting our next ‘Women in COG’ event featuring Emma Thomson, OBE, Professor in Infectious Diseases at the MRC-University of Glasgow Centre for Virus Research and a COG-UK Principal Investigator for the University of Glasgow.

On Wednesday 29th June, at 12:15 – 13:00 BST, we will be hosting our next ‘Women in COG’ event featuring Emma Thomson, OBE, Professor in Infectious Diseases at the MRC-University of Glasgow Centre for Virus Research and a COG-UK Principal Investigator for the University of Glasgow.

This event will feature a conversation with Emma followed by an informal Q&A.

REGISTER HERE

When? Wednesday 29th June 12:15 to 13:00 BST

Where? Virtual

Who can attend? Everyone

 

Professor Emma Thomson, OBE

Professor Emma Thomson, OBE, is a COG-UK Principal Investigator for the University of Glasgow and a Professor in Infectious Diseases at the MRC-University of Glasgow Centre for Virus Research. She was recently awarded Officer of the Most Excellent Order of the British Empire (OBE) for services to the NHS during the COVID-19 response. Currently Professor Thomson is heavily involved in sequencing SARS-CoV-2 as part of COG-UK. She is the local principal investigator for two vaccine trials running within Greater Glasgow and Clyde. In addition to her work with COVID-19, Professor Thomson’s main research focus is on emerging infections in Uganda, working closely with the Uganda Virus Research Institute and in the UK.

 

About Women in COG

The COG-UK consortium has over 500 members with a range of scientific and business expertise in genomics, bioinformatics, operations clinical science and public health. Women in COG is a supportive network to share experience and knowledge and to promote science careers in women and girls.

This was an event in our series of monthly lunchtime Women in COG events and everyone (regardless of gender) is welcome to attend. The events will feature a conversation with a guest or consortium member followed by an informal Q&A.

Check out our past and upcoming Women in COG events.


COVID-19 Genomics UK (COG-UK)

The COVID-19 Genomics UK (COG-UK) consortium works in partnership to harness the power of SARS-CoV-2 genomics in the fight against COVID-19.

Led by Professor Sharon Peacock of the University of Cambridge, COG-UK is made up of an innovative collaboration of NHS organisations, the four public health agencies of the UK, the Wellcome Sanger Institute and sixteen academic partners. A full list of collaborators can be found here.

The COVID-19 pandemic, caused by SARS-CoV-2, represents a major threat to health. The COG-UK consortium was formed in March 2020 to deliver SARS-CoV-2 genome sequencing and analysis to inform public health policy and to support the establishment of a national pathogen sequencing service, with sequence data now predominantly generated by the Wellcome Sanger Institute and the Public Health Agencies.

SARS-CoV-2 genome sequencing and analysis plays a key role in the COVID-19 public health response by enabling the identification, tracking and analysis of variants of concern, and by informing the design of vaccines and therapeutics. COG-UK works collaboratively to deliver world-class research on pathogen sequencing and analysis, maximise the value of genomic data by ensuring fair access and data linkage, and provide a training programme to enable equity in global sequencing.